Repositioning of drugs: Hydroxychloroquine
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چکیده
منابع مشابه
Repositioning of Thiourea-Containing Drugs as Tyrosinase Inhibitors
Tyrosinase catalyzes two distinct sequential reactions in melanin biosynthesis: The hydroxylation of tyrosine to dihydroxyphenylalanine (DOPA) and the oxidation of DOPA to dopaquinone. Developing functional modulators of tyrosinase is important for therapeutic and cosmetic purposes. Given the abundance of thiourea moiety in known tyrosinase inhibitors, we studied other thiourea-containing drugs...
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Background Schistosomiasis remains a severe problem of public health in developing countries [1]. Several reports show that praziquantel, the drug of choice for treating schistosomiasis, can select Schistosoma mansoni strains resistant to the drug. Thus, developing new drugs against this parasitosis is a highly desirable goal [2]. In this context, enzymes involved in energetic metabolism could ...
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Copyright: © 2012 Dou. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The conventional approach toward anti-cancer drug development is expensive and time-consuming. One approach to expedite this process and a...
متن کاملHydroxychloroquine screening.
A lmony et al report in this issue of the BJO (p 569) the use of a threshold Amsler grid (TAG) as a screening tool for asymptomatic patients taking hydroxychloroquine (HCQ). They studied 56 patients taking HCQ and 12 controls. Patients were tested with a ‘‘white on black’’ Amsler grid (AG), a ‘‘red on black’’ AG (RAG), and the threshold AG (TAG). TAG uses cross polarising filters to reduce the ...
متن کاملOcular toxicity of hydroxychloroquine.
OBJECTIVES To review the types, incidence, pathogenesis, risk factors, and clinical characteristics of hydroxychloroquine ocular toxicity and current views about its screening and management. DATA SOURCES Literature search of Medline up to May 2005. STUDY SELECTION Key words for the literature search were 'hydroxychloroquine', 'chloroquine', 'ocular', 'toxicity', 'retinopathy', and 'screeni...
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ژورنال
عنوان ژورنال: Journal of Mahatma Gandhi Institute of Medical Sciences
سال: 2015
ISSN: 0971-9903
DOI: 10.4103/0971-9903.151715